Syringes have been used in medicine for over a century. However, their use remains a matter of experience, which makes things difficult in some cases where precision is required. In this context, Brigham and Women’s Hospital researchers have developed a highly sensitive “smart” tissue-targeted syringe (i2T2) that perceives changes in resistance in order to deliver the drugs correctly and safely.
The relevant research was published in Nature Biomedical Engineering. “Targeting specific tissues via a conventional needle can be tricky and often requires a well trained person,” says Jeff Karp, a professor of medicine at Brigham. “In the last century there has been little innovation in the needle itself, which we have seen as an opportunity to develop better accurate means. We sought to achieve improved web targeting while keeping the project as simple as possible for ease of use, “he explains.
The i2T2 device was created by combining a normal hypodermic needle and commercially available syringes. The body tissues have different densities and the “smart” syringe utilizes the pressure differences to allow the needle to move to the target tissue. The feedbacl is immediate, allowing for better targeting and minimal error probability.
I2T2 was tested in tissues from three animal models in “difficult” areas, and the results were very positive, without even requiring special training.
“This smart syringe is a simple solution that could be quickly promoted to patients to help increase accuracy and reduce injuries from failures. We completely transformed the needles with a small modification that achieves better web targeting, “said the first author of the research, Giris Gintins. “It’s a technology platform, so the uses could be very wide,” he said.